| abstract |
A pharmaceutical composition comprising (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmacologically acceptable salt thereof and (b) an immunosuppressant. Further, there is provided a therapeutic and/or preventive agent for chronic skin disease comprising (a) a PDE-IV inhibitor or a pharmacologically acceptable salt thereof and (b) an immunosuppressant. Still further, there is provided a therapeutic and/or preventive agent for chronic skin disease comprising as active ingredients (a) a PDE-IV inhibitor or a pharmacologically acceptable salt thereof and (b) an immunosuppressant, which are administered simultaneously or separately with an interval. |