| abstract |
The present invention relates to novel ketone compounds' of formula (I) wherein, inter alla, A-B represents -NR5p'SO2-; -W- represents -CH2-, -(CH2)2-, -(CH2)3- or -C(H)=C(H)-; X-Y-Z represents -C=CR8-NR9-, having Asp2 (ß-secretase, BACE1 or Memapsin-2) inhibitory activity, processes for their preparation, to -compositions containing them and to their use in the treatment of diseases characterised by elevated ß- amyloid levels or ß-amyloid deposits, particularly Alzheimer's disease. |