| abstract |
A novel compound represented by the following general formula (I), which has the function of reducing blood phosphate concentration. General formula (I): [In the formula, A represents -(CH2)n-, -CO-, -(CH2)n-CO-(CH2)m-, -(CH2)n-CS-(CH2)m-, or branched alkylene; rings B and C may be the same or different and each represents a benzene ring, naphthalene ring, azulene ring, heterocycle, or fused heterocycle; D represents -(CH2)(n+1)-, -(CH2)n-O-(CH2)m-, -(CH2)n-S(O)o-(CH2)m-, -CF2-, or -(CH2)n-NR10-(CH2)m- (provided that D is bonded to a carbon atom as a constituent member of the ring C); E represents oxygen or sulfur; P represents phosphorus; R1 to R7 may be the same or different and each represents a substituent (provided that R1 and R4 may be bonded respectively to R2 and R5 in cooperation with the adjacent carbon atom to form a 5- to 7-membered (un)saturated hydrocarbon ring or 5- or 6-membered fused heterocycle, and that when ring B is a benzene ring, not all of R1, R2, and R3 are hydrogen); and R8 and R9 may be the same or different and each represents a substituent; provided that R10 represents hydrogen, alkyl, etc., n and m each is an integer of 0-10, and o is an integer of 0-2.] |