http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006031976-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ccc5ea34f8d48af7f691313de8f4fa7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef8d035f90fa04424942cf445be4fb94 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2005-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b15e61ca5cefce41bb41500ee36eba9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88a1680fdaf6100cead77958be0be407 |
| publicationDate | 2006-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006031976-A3 |
| titleOfInvention | Compositions and methods for treating stat-6 associated diseases or conditions |
| abstract | The present invention relates to a cell permeable peptide to specifically inhibit tyrosine phosphorylation and/or subsequent activation of STAT-6. This peptide is composed of a protein transduction moiety operably linked to a portion of STAT-6 which contains tyrosine residue 641 (Tyr-641) of STAT-6, wherein Tyr-641 is phosphorylated. The chimeric STAT-6 peptide enters cells and binds to the SH2 domain of wild-type STAT-6, and subsequently inhibits dimerization and nuclear translocation of the wild-type STAT-6 protein. Administration of this chimeric peptide inhibits allergen-induced airway inflammation, cytokine production and airway hyperresponsiveness and is useful in methods for preventing or treating diseases or conditions associated with STAT-6 activation. |
| priorityDate | 2004-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.