| abstract |
Formulations are described to improve the delivery of poorly soluble drug agents such as anthelmintic compounds on injection to animals. In one particular example of a complexed ricobendazole anthelmintic formulation given to a sheep, drug absorption and by association bioavailability, was increased significally compared to existing formulations. In addition the invention formulations were well tolerated by test animals with minimal side effects or tissue reactions. One advantage of the formulations of the present invention is that dosages may be able to be decreased owing to the superior absorption and resulting comparable efficacy with other methods. |