| abstract |
This invention discloses a method and formulation for treatment / prevention of human and animal cancers. The invention is designed to exploit the vulnerability of cancer with regards to its anaerobic requirement for non-oxidative phosphorylation of glucose to derive energy, being opposite to the host. The composition is comprised of one or more of (A) 2,3-dimethoxy-5-methyl-1,4-benzoquinone, ubiquinones (5-45) (B) compound(s) capable of augmenting oxidative phosphorylation such as a riboflavin containing compound and/or ubiquinone (50) (C) 2',3,4'5,7-pentahydroxyflavone and/or a lactic acid dehydrogenase inhibitor and (D) compounds (s) that antagonize anapleurotic carboxylating pathways and gluconeogenesis from non-glucose carbon based substrates. This combination favors oxidative loss of carbon through decarboxylation reactions, suppresses carbon integration through gluconeogenesis and initiates collapse of ATP produced through glycolysis in tumor tissue, events which should be non-toxic or perhaps even beneficial to normal respiring host tissue. Pilot studies indicate the treatment to be potent without side effects. |