| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_384b4548f52d1a02046dd0b667362f7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fe6ef8d167eaf3c72db2fcafc50980e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9861d792705be5b367378babb3cf466
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1418bd44620fc2469a61065dbfb960ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2213e522a5b9db21ae7a85b914015b39 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-645 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 |
| filingDate |
2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58f1a29183eac7e9b23c54f51dfea3bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e004a699191ff9e7aba0b774af092a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_302edb20d19b2f0653be223ef7d11748
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f83490a5626f32d2199edf1679098418 |
| publicationDate |
2006-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006014872-A2 |
| titleOfInvention |
Novel processes for stereoselective synthesis of trans isatx 247 |
| abstract |
The present invention relates to a process for preparation of a trans ISATX247 compound of the formula: where R1 = H or D; R2 = H or D; and R3 = H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene (the acetate of trans ISATX247) and deacetylating the acetyl cyclosporin diene to produce the trans-isomer of ISATX247. The present invention also relates to a process for preparing the same trans ISATX247 compound, using olefin cross metathesis. The process involves: olefin cross metathesis of acetyl cyclosporin A to afford acetyl cyclosporin α,β-unsaturated aldehyde; Wittig reaction of the acetyl cyclosporin α,β-unsaturated aldehyde to provide acetyl cyclosporin diene; and deacetylation of the acetyl cyclosporin diene to produce the trans ISATX247 compound. Also disclosed are processes for preparing an acetyl cyclosporin α,β-unsaturated aldehyde compound and a cyclosporin triene analogue compound. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11584779-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7696165-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4201952-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020082061-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023118045-A1 |
| priorityDate |
2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |