| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f1bfff223851d39d97c0228c37a87f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_070e94d859f098a913b281165eae8210
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0bbbe53b0329fc1a82458e2c4d8693f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4c3406b8dd20799ebdeb226f5fb7e88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41f1327ec83bfea7b97d74cb157260dd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0661 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2005-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43c015ceb488b022423f07a71c5d58f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9c74441f1bee7af6fcf10f3729f943c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9061fb9ade3ac30c04520bdf0caace90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a57da970577be191d598aaddad60e3be |
| publicationDate |
2006-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006013354-A1 |
| titleOfInvention |
Method for determining the selectivity of a pre-synaptic neuromuscular blocking substance |
| abstract |
The invention relates to a method for determining the quantity of pre-synaptic neuromuscular blocking substance (notably botulinum toxin) contained in a sample. In one aspects, the method comprises the following steps: (i) determining the minimum voltage Vmsm needed to induce the contraction of a smooth muscle tissue, said smooth muscle tissue being linked to an electrical stimulator through an electrically conducting liquid and preferably immersed in an oxygenated physiological buffer containing glucose; (ii) adding the sample containing the pre-synaptic neuromuscular mocking substance; (iii) electrically stimulating, at a voltage at least equal to Vmsm, the smooth muscle tissue at certain time intervals; (iv) comparing the effect induced by the sample to the effect induced by a reference substance and thereby determining the quantity of the pre-synaptic neuromuscular blocking substance in the sample. The invention also relates to a method for determining the selectivity of a pre-synaptic neuromuscular blocking substance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114621921-A |
| priorityDate |
2004-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |