| abstract |
The present invention relates to compounds of the general formula (I); wherein Rl is halogen; R2 is -C(O)NH2,-C(NH2)=N-OH, -C(O)CH2Br, -C(O)N(CH3)OCH3 or-C(O)-lower alkyl, or is a 5-membered heteroaryl group, containing 2 or 3 heteroatoms, selected from the group consisting of N, O or S, optionally substituted by R3, wherein R3 is lower alkyl, -NR'R' or -C(O)R; R is NR'R', lower alkyl, or lower alkoxy; R'/R' are independently hydrogen or lower alkyl; as well as their pharmaceutically acceptable salts for the treatment of diseases, which are mediated by monoamine oxidase B inhibitors, for example Alzheimer's disease and senile dementia. |