| abstract |
The invention relates to N-phenylphosphonic acid triamides of general formula (I), to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea hydrolysis. In formula (I), X represents oxygen or sulfur; R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, independent of one another, represent hydrogen C<SUB>1</SUB>-C<SUB>8</SUB> alkyl/heteroalkyl, C<SUB>2</SUB>-C<SUB>8</SUB> alkenyl/heteroalkenyl, C<SUB>2</SUB>-C<SUB>8-</SUB>alkynyl/heteroalkynyl, C<SUB>3</SUB>-C<SUB>8 </SUB>cycloalkyl/heterocycloalkyl, C<SUB>3</SUB>-C<SUB>8</SUB>cycloalkenyl/heterocycloalkenyl, C<SUB>6</SUB>-C<SUB>10</SUB> aryl/C<SUB>5</SUB>-C<SUB>10</SUB> heteroaryl, aralkyl, heteroarylalkyl, alkaryl, alkheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, hetaroyl, acyloxy, aroyloxy, hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, alkylsulfonyl, fluorine, chlorine, bromine, iodine, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, with the provision that: at least one radical R is not hydrogen; in the event R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP> represent H, R<SUP>3</SUP> is not nitro or cyano, and; in the event R<SUP>1</SUP> represents Cl or R<SUP>1</SUP> and R<SUP>3</SUP> represent Cl, at least one of the remaining radicals is not hydrogen. |