http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006010020-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c8b153dc91f3f77a49c17d520499478 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40aaaca6a0cd41fca08b697b9831a6ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5dd388a5130b0bdede0fdfc6c2af6ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25f9749cd8c42c45d9649f910076dddc |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
| filingDate | 2005-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49b9be92d6e95d8f7099fd55e3f396a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_172e69c2a253bb2272ef92b96f74051a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_581d6d39f5477e62d0316944e9f37559 |
| publicationDate | 2006-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006010020-A2 |
| titleOfInvention | T cell hybridomas |
| abstract | The present invention provides T cell hybridomas and related compositions and assay systems for investigative, diagnostic, and therapeutic use in modulating T cell receptor (TCR)-mediated immune response. The T cell hybridomas of the invention are typically constructed by fusing a naïve or early central memory T cell isolated from a mammalian subject with an immortalizing fusion partner (e.g. mammalian lymphoid tumor cell) to yield clonal T cell hybrids. The resulting T cell hybridomas exhibit antigen (Ag)-specific proliferation responsiveness over a background level of proliferation of the hybridomas. These hybridomas are useful for screening, identifying, and characterizing T cell immune modulatory agents, for example recombinant T cell receptor ligands (RTLs) and other agents that can modulate TCR-mediated T cell immune responses. Ag-specific proliferative response profiles exhibited by the T cell hybridomas of the invention show sufficient amplitude, sensitivity and fidelity to distinguish and/or quantify the presence and/or activity of a test RTL or other test modulatory agent in screening and sensitivity assays employing the hybridomas. These and other aspects of the invention yield powerful tools and methods for developing and characterizing novel RTLs and other immune modulatory agents for use in treating immune disorders, including a wide range of autoimmune diseases, in mammals. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3284819-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018033544-A1 |
| priorityDate | 2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1174.