| abstract |
A time-resolved fluorescence deAce is described Or the detection and diagnosis of diabetes in a noninvasive manner The device uses an ultra-short excitation pulse of light in the UV, infrared or visible range that comprises of a repetition of nanosecond pulses. The excitation pulse is directed incident onto a strategically selected area of the patient body such as the forearm, the feet, and the palm. This light interacts with the different layers of the skin. The absorbed light excites the AGEs in the skin, which in turn generate a fluorescence signal, which is collected bV8detector. A processor is coupled to the detector to measure the transient fluorescence intensity decay of the skin in terms of lifetimes, and the contribution of individual fluorophores to the overall fluorescence signal. The nature and location of the fluorophores may be identified and a medical diagnostics may be performed. |