| abstract |
The production of polysubstituted cyclobutanes and polysubstituted cyclobutenes according to the prior art necessitated special substrates and reaction conditions, thus being poor in generality. Further, the industrial production of polysubstituted cyclobutanes was problematic in the kind or amount of the catalyst or solvent to be used. The invention provides a process for the production of polysubstituted cyclobutanes with high stereoselectivity which is applicable to industrial practice from the standpoints of operation, substrate generality, catalyst, solvent, and efficiency and is ecologically advantageous by virtue of its low environmental load. Namely, polysubstituted, cyclobutane, cyclobutene, or bicyclo[4.2.0]octane compounds can be produced efficiently, stereoselectively and ecologically advantageously by making a Brønsted acid act on a mixture of an enol ether or a 2-siloxydiene compound with an alkene or alkyne compound substituted with carbonyl at the 1-position either without a solvent or in a nonaqueous solvent. |