| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e978e1c04cd262dbea9e0fd92a64a3bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8d5c6c8598764768fb865f038ac3340
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df0dedd3192519348783fd71956732f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634f9eaf572cc875324ed64fa6f7bc77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6adf63843ce4abfe4ec5c4f697b4176 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0478
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F13-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate |
2005-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_377fd1b2e6993deb6dac6ac7ccbaf62e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d684cd60f05bfba45d43d179ddaddf59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7e394aaed0614152908cdfbb3f5f76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d88417072129321fc7616026653485e |
| publicationDate |
2006-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006008496-A2 |
| titleOfInvention |
Improved n4 chelator conjugates |
| abstract |
The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-functionalised at the bridgehead position and provides both flexibility and a lack or aryl groups, to minimise lipophilicity and steric bulk. Protected versions of the chelators are provided, which permit conjugation with a wide range of targeting molecules without interfering reactions with the amine nitrogens of the tetra-amine chelator. Syntheses of the functionalised chelators are described, together with bifunctional chelate precursors. Radiopharmaceutical compositions comprising the technetium metal complexes of the invention are described, together with non-radioactive kits for the preparation of such radiopharmaceuticals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010526774-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011073340-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012041862-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012175702-A1 |
| priorityDate |
2004-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |