http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006007310-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2614fe7c3e230c8b4ea067ef0cb34f5b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366 |
| filingDate | 2005-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_002a7f9a6423d0e75d4077d9de2f4533 |
| publicationDate | 2006-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006007310-A2 |
| titleOfInvention | Compositions of stable bioactive metabolites of docosahexaenoic (dha) and eicosapentaenoic (epa) acids |
| abstract | An invention that adduces cogent evidence to establish that oxygenated dibenzo-α-pyrones (DBPs and their conjugates), the major bioactives of shilajit (Ayurvedic vitalizer), have their origin, at least partly, in EPA and DHA. Earlier research has shown that, in mammals, C-20 PUFAs are metabolized by oxygenases and other enzymes to produce short-lived prostaglandins, leukotrienes and thromboxanes that bind to specific G-protein-coupled receptors and signal cellular responses, e.g., inflammation, vasodilation, blood pressure, pain etc. But never before it was suggested/shown that C20:5n-3 PUFAs, e.g., EPA (and DHA), are transformed into stable aromatic metabolites, DBPs, which elicit a large array of bioactivities in the producer organisms and also control the synthesis and metabolism of arachidonate-derived prostaglandins. The major beneficial effects attributed to EPA and DHA are now found to be largely contributed by DBPs and their aminoacyl conjugates and the dibenzo-α-pyrone-chromoproteins (DCPs). Because of the highly unstable nature of EPA and DHA, when administered, they are metabolized into a large array of uncontrolled products, several of which are systemically undesirable. By contrast, DBPs, because of their stability, perform the biological response modifier (BRM) functions in a directed and sustained way. Many of the biological effects of DBPs described in this invention, were earlier attributed to EPA and DHA, - the precursors of DBPs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2020200420-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11020373-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101498671-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180468-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10532992-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013115619-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013115619-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9994542-B2 |
| priorityDate | 2004-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 334.