http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006006184-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee74c5988007684da193b516c3a8697a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d893517a120df5e7603f09b3c3c010d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75361dbce985e566043dcc2bce25bd13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_234b0be81a66109f82a02a23a59c1d64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4df720385848704d2ca8dda6d63af25a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00 |
| filingDate | 2005-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a06172405db901d84d6d556a79d05b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d7bdcd6fd8403bbc93e0618b0500c5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2697899668d35d4d685e8728eb004cce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ccc11edc486b90e9d1308c82b965c23 |
| publicationDate | 2006-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006006184-A2 |
| titleOfInvention | A process for the manufacturing of loratadine and its intermediates |
| abstract | The process comprises (i) subjecting substituted benzyl halide to cyanation in a biphasic system using water immiscible solvents by any known methods, (ii) condensing in situ the phenyl acetonitrile thus obtained with nicotinic ester in presence of alkali metal alkoxide and water immiscible organic solvent to produce ketonitrile, (iii) hydrolyzing followed by decarboxylating the said ketonitrile in situ to respective ketone in acid environment below 60° C, (iv) subjecting the ketone so obtained to reduction followed by N-oxidation, cyanation, and hydrolysis by any known methods to produce picolinic acid, (v) cyclising the said picolinic acid to tricyclic ketone by conventional methods, (vi) treating the said tricyclic ketone with organometallic compound containing Mg to produce carbinol, (viii) purifying the said carbinol with purifying agent selected from polar water miscible organic solvent followed by dehydrating with neat sulphuric acid at the temperature below 50° C, to get N-methyl product (olefin), and subjecting the said olefin to N-carbethoxylation to produce loratadine. Loratadine can also be prepared by treating cayano compound with organometallic compound containing Mg to produce a ketone by the methods known in the art followed by cyclising in presence of a mixture of sulfuric acid and a source of boric acid to get N-methyl product and converting to loratadine by N-carbethoxylation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102336739-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102336739-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112341433-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113135893-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114085209-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113135899-A |
| priorityDate | 2004-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 144.