| abstract |
Stabilized pharmaceutical composition comprising a therapeutically effective amount of one or more active pharmaceutical ingredients capable of degradation in a low pH environment and a stabilizing effective amount of one or more amino-group containing monomeric compounds and/or amido-group containing monomeric compounds for the stabilization of the active pharmaceutical ingredientare provided. The present invention also provides for the use of such stabilized pharmaceutical compositions for the treatment of dyslipidemias including, for example, hyperlipidemia, hypercholesterolemia and hypertriglyceridemia. Preferred active pharmaceutical ingredients are a statin such as pravastatin or atorvastatin. Preferred stabilizing compounds are meglumine, triethanolamine, tromethamine or sodium chloride. The composition is preferably in form of a tablet or granules. |