| abstract |
The invention relates to a composition that can inhibit the growth of tumour cells of different histological origins and activated endothelial cells. The components of said composition are polypeptide fragments of serralysins, corresponding to the C-terminal fragment, from the internal methionine of the sequence to the end of the molecule, which can be combined with one another and, optionally, with prodigiosins which potentiate the anti-tumour effect of the composition. The prodigiosins in the composition can be at a concentration of between 0.1 - 100 nM. The anti-proliferative action of the composition is provided by apoptotic mechanisms. The in vivo administration of the inventive composition has an anti-tumour effect, an anti-angiogenic effect and protects against malignant tumours. |