| abstract |
This invention is directed to substituted imidazole compounds which modulate the activity of KSP and are useful for the treatment of cancer and are represented by the formula (I) wherein: R1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; R2 is selected from the group consisting of hydrogen, alkyl, and aryl; R3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-, -S(O)2-, and -S(O)2-N(R)-, where R is hydrogen or alkyl; and A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents; R5 is selected from the group consisting of L-A1, wherein L is selected from the group consisting of-S(O)q- where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and one of either R6 or R7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R8)m where R8 is as defined herein and m is an integer from 1 to 3, and the other Of R6 or R7 is selected from the group consisting of hydrogen, halo, and alkyl; or R6 and R7 are both hydrogen; the other substituents are defined in the claims. |