Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_555896a2f43ea629dbc0f99b94cfd297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_758b18878e7620a31ad005f8909e75c8 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
filingDate |
2005-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3e0b31bc8dd3ac4c2034d7a36e91c30 |
publicationDate |
2006-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2006002049-A2 |
titleOfInvention |
Methods for predicting methotrexate polyglutamate levels using pharmacogenetics |
abstract |
The present invention provides methods for determining a level of methotrexate polyglutamates (MTXPGs) in an individual undergoing methotrexate (MTX) therapy and for optimizing dose efficacy of MTX therapy in an individual by genotyping the individual at a polymorphic site in at least one folate pathway gene (e.g., a reduced folate carrier (RFC-1) gene, a gamma glutamyl hydrolase (GGH) gene, etc.). Methods are also provided for determining a level of MTXPGs in an individual undergoing MTX therapy and for optimizing dose efficacy of MTX therapy in an individual by generating a pharmacogenetic index based upon the genotype of the individual at a polymorphic site in an RFC-1 gene and/or a GGH gene. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11534498-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2722404-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11344628-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109689104-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1877579-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3496757-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11771700-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4052729-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1877579-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11779584-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730738-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11701432-B2 |
priorityDate |
2004-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |