| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13e9f69d1c2e0b5d25c6d1912f8ed493
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64aa04c65db53105d13ae7511df7e708
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f9557f452eb7a184dda5d6b10d9a0b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d29f64ac8769f5e91de3a38618507de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a26659bea7d007f2c07b23a3539e4de |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0333 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-033 |
| filingDate |
2005-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ba31c592b14f2cb48b23366451df1ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b305c79a926f05dec484cabb660a0c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5281ff2350abf78bb0770824889cae99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbd173be5bf9f595e5a5fea629982600 |
| publicationDate |
2005-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005123962-A2 |
| titleOfInvention |
Gene targeting in eukaryotic cells by group ii intron ribonucleoprotein particles |
| abstract |
Provided herein are methods of disrupting DNA substrates in eukaryotic cells and methods of introducing exogenous polynucleotides into target sites in the DNA substrates In certain embodiments the methods comprise introducing a purified group II intron ribonucleoprotein (RNP) particle into the host cell. In certain embodiments the method comprises introducing a group II intron RNP particle and a DNA construct comprising an exogenous polynucleotide flanked by sequences that are homologous to sequences that flank the target site in the endogenous DNA substrate. In certain embodiments, the methods also involve introducing magnesium ions into the eukaryotic cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11331346-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11083753-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11033584-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10544422-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11590171-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7592161-B2 |
| priorityDate |
2004-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |