http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005123771-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7cfdbc26aee76c0d3c31b9f9d429821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcd60ddea45718aedcd5f70f00ef8391 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_506e66e4ce9c9fca798bd055394d54a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1fbb22d7954557801160a9fd579bae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_466dde5c605f067a292a3d9ea5b40e04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-57 |
| filingDate | 2005-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9384c50822e14c3ad1d298c2bcc107b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92ca944afc7fb82e6bf77711fc61c6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b63cd453f9122649905dba1ee9739ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef1dce2d04c2df810327f812d32647cc |
| publicationDate | 2005-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005123771-A2 |
| titleOfInvention | Oligomeric peptides and their use for the treatment of hiv infections |
| abstract | The invention relates to oligomeric peptides with biological activity against HIV infection having the amino acid sequence (Z1-LE-X1-IP-X2-X3-X4-P-X5-X6-X7-X8- X9-X10-K-X11-X12-X13-X14-X15-Z2)n, wherein n indicates the number of monomeric peptide chains, whereby n is 2, 3 or 4; X1 is a lysine, alanine, or aspartic acid; X2 is a cysteine, methionine or isoleucine; X3 is a serine, cysteine, lysine or glycine; X4 is an isoleucine, alanine, phenylalanine or cysteine; X5 is a proline, D-proline or a substituted L-or D-proline; X6 is a cysteine or glutamic acid; X7 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X8 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X9 is an amino acid with an aromatic side chain; X10 is a glycine, alanine or asparagine; X11 is a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X12 is a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4tetrahydroisoquinoline-3-carboxylic acid; X13 is an amino acid with a hydrophobic or an aromatic side chain; X14 is an amino acid with a hydrophobic or an aromatic side chain; X15 is a phenylalanine or deletion; Z1 is NH2 or a sequence of 1 to 10 amino acid residues; Z2 is COOH or a sequence of 1 to 10 amino acid residues; and oligomeric peptides which are fragments thereof and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof; and with the proviso that (a) if X12 is alanine, glycine, glutamic acid, or D-1,2,3,4tetrahydroisoquinoline-3-carboxylic acid than X13, X14 and X15 are phenylalanine, valine and phenylalanine respectively; and/or (b) if X12 is phenylalanine, than X13, X14 and X15 are valine, phenylalanine and a deletion, respectively; and (c) there are at maximum three cysteine residues in a peptide; and (d) the oligomeric peptide has not the sequence (LEAIPCSIPPEFLFGKPFVF)2 (VIR-576); and (e) the monomeric peptide chains are not linked by peptide bonds between the N- terminus of one peptide chain to the C-terminus of another peptide chain. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2479193-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1954302-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1954302-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711053-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011042762-A3 |
| priorityDate | 2004-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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