| abstract |
The invention relates to a method and device for the in vitro detection of polycystic ovarian syndrome (PCOS) and pathologies involving cardiovascular risk. More specifically, the invention relates to an in vitro test device (kit) and method for the diagnosis of the presence of, or predisposition to PCOS and/or cardiovascular risk factors including general obesity, abdominal obesity, hypertension, glucose intolerance, diabetes, hyperinsulinaemia, general hypercholesterinaemia, hypercholesterinaemia with high cholesterol levels associated with LDL, low cholesterol levels associated with HDL and hypertriglyceridaemia, as well as a combination of some of said cardiovascular risk factors, known as metabolic syndrome. The inventive method and kit are characterised in that they are based on the detection of at least one genotype or haplotype of a polymorphism in gene CAPN5 selected from among: Nt g.86 A>G, Nt g.344 G>A, Nt c.1320 C>T, and Nt c.1469 G>A, or combinations of same. |