http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005115443-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84186219c8f13a30a06a94fbec131154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fb7b45af8f8ec3b10ad8383c1266644 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b76a6192507a1b8376cef3d49ce846fb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-79 |
| filingDate | 2005-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a2ef93d16110e2e35b5a76391f3961 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd4eea02db739e362d6b4c986e3f1586 |
| publicationDate | 2005-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005115443-A1 |
| titleOfInvention | Chronic articular inflammation-modulating composition based on collagen-polyvinylpyrrolidone |
| abstract | The invention relates to a chronic articular inflammation-modulating composition which uses collagen-polyvinylpyrrolidone. Collagen turnover is modulated using collagen-PVP in patients with rheumatoid arthritis and osteoarthritis, since the biocomplex negatively regulates collagenolytic activity and increases the content of type III collagen and TIMP-1 to levels similar to those observed in normal synovia. In this way, the chronic inflammatory process is altered by the collagen-PVP, as described above, owing to the negative regulation of IL-1, the TNF- of IL-8 and the adhesion molecules, since said molecules can induce the expression and activation of collagenolytic enzymes, as well as the proliferation and migration of synovial cells by means of the adhesive mechanisms including the adhesion molecules, and the induction and activation of Cox-1. In addition to cellular anchoring, the interaction of the extracellular matrix integrins generates signals which regulate the expression of MMPs, suggesting that the adhesion molecules can also play a part in tissue destruction associated with rheumatoid arthritis. Moreover, the decrease in the synthesis of TNF- and IL-1 appears to stimulate the cell death of synoviocytes by means of apoptosis, which, in turn, seems to contribute to the inhibition of the proliferation of synovial cells, the formation of pannus and the destruction of the articular tissue. |
| priorityDate | 2004-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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