| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_799bd66978d6c3018225a3a4b00d310a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a490020fd2580d5f04cbe4ea55b65c3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_142e31acf95b26c62a2e1dcf16b73e8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff53a6b1a014fe5dbcb895a74869e04d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70539 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-505 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 |
| filingDate |
2005-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d01e5e5b10c15b35269e49ba3485128f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3456e5b9f9e23c1834a80ebbe0cab8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e2766faf898f6a0c17d510b6acfea22 |
| publicationDate |
2005-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005111624-A2 |
| titleOfInvention |
Mhc bridging system for detecting ctl-mediated lysis of antigen presenting cells |
| abstract |
A bridging assay that utilizes a multivalent MHC binding molecule to enumerate the number of antigen-specific CTLs in a particular sample and also determines the functional capability of the CTL population in the sample is provided. In one embodiment, the assay is used to measure the effector function of any tetramer-positive CTL using a single non -MHC-containing target cell line that is adapted to form an antibody bridge with the tetramer. Furthermore, effector function and enumeration can be measured by flow cytometry, and additional markers residing on either effector or target cell populations may be detected using antibodies coupled with other fluorochromes. The tetramer bridging assay will allow investigators to easily determine the lytic capacity and antigenic specificity of CTLs using a commercially available reagent in a non-radioactive assay. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11668705-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11402373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11585806-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020247725-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3620465-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10481158-B2 |
| priorityDate |
2004-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |