| abstract |
The invention relates to the diagnosis components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of protachykinin and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker peptide for medical diagnostics as well as for the diagnostic detection of the course prognosis and course control of diseases/disorders of the central nervous system, comprising Alzheimer's disease, Parkinson's disease, depression and/or conditions of pain, neurological, endocrinological, cerebral, muscular, local, systemic, chronic, inflammatory diseases, infectious diseases comprising bacterial and viral infections, meningitis, sepsis, Crohn's disease, colitis ulcerosa, sickle cell anemia, ischemia, amyotrophic lateral sclerosis, arthritis comprising rheumatoid arthritis, bronchitis, hyperalgesia, asthma, intoxication comprising bacterial intoxication, immunological disorders, poly/-trauma comprising cranio-cerebral trauma, tumors/cancer, stroke, stress, atopis dermatitis, HIV, Huntington's disease, burns, schizophrenia, Hirschsprung's disease, allergies, familial dysautononmia (Riley Day syndrome), hematopoietic disorders, gliomas comprising glioblastomas and astrocytomas, disorders of the blood brain barrier. The invention further provides antibodies for binding to certain proteins and their fragments, more specifically protachykinin and its fragments. In accordance with the invention, a kit useful for the above-mentioned diagnosis is also provided. |