http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005102305-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6dc60bbad0c80f9a40232d804874685e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8cafbcaa29a1d5136eae62938d70054e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23abca784bd14474bcaf12ac32819c47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ab6f251f3db562f2025e279b014193f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86a6a3d47d2ac7842fe17c6af9148360 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9f7f0df5f546b7228e5d137d2a733f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a2d0d7477940d2aa4174e07783e54b2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-195 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195 |
| filingDate | 2005-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_117daf1ad4d06cbb28ff8c2d72b63b3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac000cb9fa5a53123c7d68fb02993803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38259cb2a995cf807dd5df1113c1fbba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee4fb91be1e8bd8976d1574018af6f57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7767af8759d81cb9cd4a1a3d803e110a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaefe3758916cc2a5b1ccbc998119f24 |
| publicationDate | 2005-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005102305-A2 |
| titleOfInvention | Compositions of allosteric hemoglobin modifiers and methods of making the same |
| abstract | ABSTRACT The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products. |
| priorityDate | 2004-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.