| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd739970d4db04a7985ecd1bbe14c0f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9019c0ce5cb7b82c85e121f6cac86dce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1d5b3f35799b9edd167edcf83df09a6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2005-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9615b1c981544dcb388f0eb3d5c7984d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bb3c4725c79eafbc25111ba4d9c0697 |
| publicationDate |
2005-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005102040-A1 |
| titleOfInvention |
Tlr ligand and il-1 response-injured animal model |
| abstract |
It is intended to provide a TLR ligand/IL-1 response-injured nonhuman animal model in which the IL-6 production responding to TLR ligand/IL-1 is injured; and a method of screening a promoter or an inhibitor of the TLR ligand/IL-1 response or a preventive/remedy for atopic dermatitis-like inflammatory skin disease lesions by using this nonhuman animal. A TLR ligand/IL-1 nonresponsive nonhuman animal model, in which an endogenous gene encoding IκB-ζ of a nonhuman animal has been entirely or partly inactivated by a gene mutation such as breakage, deletion or substitution so as to lose the function of expressing IκB-ζ and thus the IL-6 production responding to the TLR ligand and IL-1 is injured, is constructed. By using this nonhuman animal and a test substance, a promoter or an inhibitor of the TLR ligand/IL-1 response or a preventive/remedy for atopic dermatitis-like inflammatory skin disease lesions is screened. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7629135-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007050531-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7432343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007050531-A2 |
| priorityDate |
2004-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |