| abstract |
The invention provides a human TACR1 which is associated with the cardiovascular diseases, infections, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, reproduction disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, reproduction disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TACR1 as well as pharmaceutical compositions comprising such compounds. |