Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_555d1481144634a776ec89114def5961 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f321663caa70c069651bab3c051194b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e24286195eb98ca9fd4e9eb1ff2df539 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 |
filingDate |
2004-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bb6cb551de1f2c9d8e3b2dc3c3ca231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da0b83d8bfa7701fd67342d50c10bd8d |
publicationDate |
2006-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2005099353-A3 |
titleOfInvention |
A novel process for the preparation of linezolid and related compounds |
abstract |
The present invention provides a novel process for preparation of 5-aminomethyl substituted oxazolidinones, key intermediates for oxazolidinone antibacterials including linezolid. Thus linezolid is prepared by a) reacting 3-fluoro-4-morpholinyl aniline with R-epichlorohydrin; b) subjecting N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline produced above to carbonylation; c) reacting (5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone produced above with potassium phthalimide; d) reacting (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide produced above with hydrazine hydrate; and e) reacting S-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine produced above with acetic anhydride to produce linezolid. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006275-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859596-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846743-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846741-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9309200-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365512-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865753-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835475-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9586942-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846730-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9238619-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8841334-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8735434-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8877794-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9586945-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9193713-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9096619-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8883839-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8957089-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8895592-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9227930-B2 |
priorityDate |
2004-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |