| abstract |
Aldosterone receptor antagonists containing compounds having dihydropyridine skeletons, for example, compounds represented by the general formula (I) or salts or prodrugs thereof: (I) wherein R1, R2, R3, and R4 are each independently hydrogen, halogeno, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, optionally substituted hydroxy, optionally substituted mercapto, optionally substituted amino, optionally esterified carboxyl, optionally substituted carbamoyl, optionally substituted sulfamoyl, acyl, cyano, or nitro; R5 is hydrogen, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or acyl; R6 is hydrogen, optionally substituted alkyl, optionally esterified carboxyl, optionally substituted carbamoyl, an optionally substituted aromatic group, or cyano; and Ar is an optionally substituted aromatic group. |