| abstract |
The invention relates to nucleic acids and polypeptides referred to herein as cospeptin and cosmedin. Cospeptin, cosmedin, analogs and mimetics thereof act in signaling pathways, and are shown to modulate hypertension and other cardiovascular parameters, and gastric emptying. Cospeptin and cosmedin nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing the polypeptide; and in studying associated physiological pathways. |