| abstract |
An 8-oxoadenine compound represented by the formula (1): [wherein ring A represents a 6- to10-membered aromatic carbocycle, etc.; R represents halogeno, alkyl, etc.; n is an integer of 0 to 2; Z1 represents alkylene; X2 represents oxygen, sulfur, SO2, NR5, CO, CONR5, NR5CO, etc.; Y1, Y2, and Y3 each independently represents a single bond or alkylene; X1 represents oxygen, sulfur, NR4 (wherein R4 represents hydrogen or alkyl), or a single bond; R2 represents (un)substituted alkyl, etc.; and R1 represents hydrogen, hydroxy, alkoxy, alkoxycarbonyl, haloalkyl, etc.] or a pharmaceutically acceptable salt thereof. They have immunoregulatory activity such as interferon-inducing activity and are useful as an antiviral agent, antiallergic, etc. |