| abstract |
A process is provided for the preparation of lipophilic monoesters of formula (3) and their stereoisomers. The process includes the steps of esterification of a phosphonate with a lipophilic alcohol, then allowing the resultant product to react with a suitably protected nucleoside in the presence of a strong base. In certain embodiments, the process is used for the preparation of alkyl or alkoxyalkyl lipid ether monoesters of nucleoside phosphonates which are useful as antiviral, anticancer or antiparasitic agents. |