| abstract |
The present invention provides cylclic hexapeptides, microcionamides A and B, isolated from the Philippine marine sponge C/athria (Thalysias) abietina. These new hexapeptides are cyclized via a cystine moiety and have their C-terminus docked by a 2-phenylethylenamine group. The compounds exhibit cytotoxicity against human brean cancer cells lines and displayed inhibitory activity against Mycobacterium tuberculosis. The structure of the compounds was determined to be of formula: (I). |