| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d17bf25392de3a56bf25c933537bea65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afcf56d89230bea59e165125422f7bb7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38f6403d850a1fe9e34ef7fd5a010318
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e3852ac507cf3f60e2748ad36a8ed00 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate |
2005-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1299d7a2fa99f742357b36003e199360
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_978f993aed22117c8b04cc8c3e3ad73b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff940885b0fbbba90f1f46068b6efc01 |
| publicationDate |
2005-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005082924-A1 |
| titleOfInvention |
23-hetero-analogs of ornithogalum caudatum saponin osw-1, the preparation and use thereof |
| abstract |
The invention provides new compounds of 23-Hetero-analogs of Ornithogalum caudatum saponin OSW-1, the preparation and use thereof. The present invention provides a practical process to synthesize the new 23-Hetero-OSW-1 saponin including the following steps : (1) introduction of the 16 α -OH group: using acetyl dehydroisoandrosteron or its 5,6-dihydrogenated product as raw material to introduce 16 α -OH group; (2) introducing the side chain by Aldol reaction and constructing the 17 α-OH group at the same time; (3) oxidation of the 16 α-OH to ketone group; (4) inversion of the configuration of 16- OH group; (5) saccharification of the 16- OH group; (6) removing the protective group to give the purpose compounds. These compounds have potent antineoplastic activity. The structure and the synthesis process of these compounds have not been reported previously. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109430059-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8552161-B2 |
| priorityDate |
2004-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |