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filingDate 2005-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2005-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2005081801-A2
titleOfInvention Methods and apparatus for scanning small sample volumes
abstract Methods and apparatus for assaying biological materials employ multi-well substrates as described herein. The substrates (102) include a plurality of wells (201) typically each of several nanoliters volume or smaller having consistent dimensions and formed in a rigid substrate (102) s a glass disk. Each well (201) provided with a circumferential lip to minimize crosstalk between wells and/or facilitate optical location of the individual wells during interrogation. Samples are provided to the individual wells and assayed by an optical technique (119) employing fluorescence, polarization, reflectance, or the like. A scanning laser system (111) may be employed for this purpose. The substrate may rotate during the scan to allow consistent interrogation of the wells without stopping and starting the rotation. Multiple rotations may also be employed repeatedly interrogate the samples for use in a kinetic study, for example.
priorityDate 2004-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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