| abstract |
The present invention relates to the finding that plants which are deficient in geranylgeranyl diphosphate (GGDP) metabolism, in particular tomato and other carotenoid synthesising plants, are useful in the biosynthesis of taxa-4, 11-diene (taxadiene) and other paclitaxel intermediates. Methods and means of producing taxadiene and other paclitaxel intermediates using plants deficient in GGDP metabolism are provided. |