| abstract |
Pharmaceutical preparation for sustained release of a pharmaceutically active ingredient A pharmaceutical preparation for sustained release of a pharmaceutically active ingredient(s), which preparation comprises particles having an inner core (1) and a first coating (2) provided thereon, wherein said coating (2) contains a mixture of: (a) between 50% and 95% by weight of a copolymer of ethyl acrylate, methylmethacrylate and trimethylamminoethyl methacrylate chloride in a molar ratio of the three acrylates of 1 : 1.8-2.2 : 0.08-0.12, preferably of 1:2:0.1, (b) between 2% and 30% by weight of a copolymer of ethylacrylate and methacrylic acid in a molar ratio of 1: 0.8-1.2, preferably of 1:1, and (c) between 1 % and 40% by weight of the pharmaceutically active ingredient. |