http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005075449-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be408f3efb13f2303ec3682304e296ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2814646da5fc34f6429f1a2064ba1a08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc90cf26bd3b81f0f5fd1198fd26ff68 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-32 |
| filingDate | 2005-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_936d9747daf7cb949c6026d473375a9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20bd60bec56af53b3edbc6f5d0e89c09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31a29e39af3fd9a87a4f9aae06e6449a |
| publicationDate | 2005-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005075449-A1 |
| titleOfInvention | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring |
| abstract | The present invention is directed to analogs of baicalein according to formula (I): where R5 is H, (CI-C12)alkyl, (C2-C13)acyl, or an optionally substituted phenyl or benzyl group, an acyl group, a C1-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate or phosphodiester group; R6 and R7 are each independently H, (C1-C12)alkyl, (C2-C13)acyl, or an optionally substituted phenyl or benzyl or together form a -OCR1R20- group wherein each of R1 and R2 is independently H, a C1-C3 alkyl group or an optionally substituted phenyl or benzyl group; and R8 is H, OH, an O-acyl group, a C1,-C4 alkyl or alkoxy group, F, Cl, Br or I, or a pharmaceutically acceptable salt thereof, which exhibit anti-P-glycoprotein activity and methods of enhancing the bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme, especially CYP450 3A4 enzyme. Pharmaceutical compositions based upon these novel derivatives according to the present invention are also described herein. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102120737-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101721405-B |
| priorityDate | 2004-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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