| abstract |
The invention relates to a method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diols of formula (I) (and/or the enantiomer), where R<l> = H, C1-6 alkyl, C3-8 cycloalkyl or benzyl and i) R<2> = methyl and R<3> = ethyl, ii) R<2> = H and R<3> = C1-6 alkyl or phenyl or iii) R<2> and R<3> together form a group of formula -(CH2)n- with n = 4 to 6, present as free amines or as salts of di- or tri-basic organic acids, starting from 2-acetyl-2-aza-bicyclo[2.2.1]hept-5-en-3-one of formula (II) (and/or the enantiomer). The method is equally useful, depending on the starting material, for the production of enantiomerically-pure compounds, or mixtures with arbitrary enantiomeric content. |