| abstract |
It is intended to provide a compound which has an effect of inhibiting the adhesion of LFA-1 to its ligand ICAM-1 and is useful in preventing or treating inflammatory diseases and autoimmune diseases, in particular, rheumatoid arthritis, asthma, psoriasis, inflammatory bowel disease, multiple sclerosis, nephritis, rejection in transplantation, etc. An aryl sulfide derivative, in which a cyclic group such as piperidine is attached to the 4-position via a specific linker such as carbamate, or its salt. |