| abstract |
Methods, compositions, and uses are provided for modulating a steroid receptor or process mediated by a steroid receptor in a cell by administering a polypyridimine tract binding protein-associated splicing factor (PSF) polypeptide, a polynucleotide encoding the polypeptide, an isolated complex of a PSF polypeptide and a steroid receptor, and/or an agonist or antagonist thereof, in an effective amount to modulate the steroid receptor or process. Particular aspects of the invention relate to detection, monitoring, modulation, treatment and/or prevention of the onset of labor. |