http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005068471-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2b8420e2c266a4c6a30351f9e9b0b3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22dc637e45826785aebd49d63b26c09b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_863faaa576ab3a8464070e69bf3b2a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2004-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_047105d5439054fa2d31a1195ace51ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0194e4fe13b556db1a7dd9196ff1669f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aef76977f263edc7f6f2c60f4ade34f |
| publicationDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005068471-A1 |
| titleOfInvention | New crystalline forms of clopidogrel hydrobromide and methods of their preparation |
| abstract | The invention concerns clopidogrel hydrobromide in the crystalline Form I characterized by an X-ray diffraction pattern with characteristic interplanar distances d of 4.01; 4.39 and 3.17 ú and which is further characterized by bands in the infrared spectra at 1743; 1421; 1237, 760 and 728 cm-1. Clopidogrel hydrobromide in the crystalline Form II is characterized by an Xray diffraction pattern with characteristic interplanar distances d of 4.52; 3.83; 3.48 ú, as well as bands in the infrared spectra at 1754; 1436; 1317 and 1223 cm-1. Crystalline form III is characterized by the following peaks ascertained by X-ray diffraction at 20 positions: 7.796 °; 15.380 °; 18.389 °; 19.369 ° and 23.895 °. The method of preparation of clopidogrel hydrobromide in the crystalline Form I consist in precipitating the clopidogrel base dissolved in toluene with a concentrated solution of hydrobromic acid. The method of preparation of clopidogrel hydrobromide in the crystalline Form II consist in dissolving the clopidogrel base in an organic solvent and precipitating it with a solution of hydrobromic acid in toluene or with gaseous hydrogen bromide. Form III can be used for the preparation of pharmaceutically applicable Form II. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005103058-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-010831-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150112975-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7652139-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2107061-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1970054-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7897613-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102238292-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1618113-A1 |
| priorityDate | 2004-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.