http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005065046-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2f33954c77b8e85845b7a976ba2059a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bde592a468dbc5068733e9b7712fb1bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9aaad810d986791598c15c3682bdc60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00177611ebc36f9326d51c971089765a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de3514051180b8701d02930ae14be882 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 |
| filingDate | 2004-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adf9f2df097ca66b027452c4ccc10431 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae0482fa7f698f0ca65db93a93f53511 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_878dbede834e407188ae7282fcb5ce27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd170dd2a7f428a125094ee2b9f9edff |
| publicationDate | 2005-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2005065046-A2 |
| titleOfInvention | An efficient industrial process for 3-hydroxy-3-(3’-sulfamyl-4’-chlorophenyl)phtalimidine |
| abstract | The oximination/cyclization of 2-(4-chlorobenzoyl)benzoic acid with hydroxylamine hydrochloride in presence of molar quantities of inorganic base in water or in alcoholic solvents to form 4-(4’-chlorophenyl)-5,6-bent-oxazine-l-one Formula (8) in high yield and purity; reduction of latter with zinc metal and acetic acid to the corresponding phtalimidine of Formula (9); followed by conversion into 2-(3’-chlorosulphonyl-4’-chlorophenyl)phtalimidine Formula (10) by reaction with chlorosulphonic acid and thionyl chloride in the absence of solvent. Amidation of compound of formula (10) was carried out with ammonia gas/solution in non.-aqueous solvent like ketones and polar aprotic solvents like dimethylformamide, to yield compound of formula (11). Oxidation of Formula (11) with hydrogen peroxide in presence of alkali results in high yield of chlorihalidone. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018158777-A1 |
| priorityDate | 2004-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 178.