| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f97a0a5e4af3e614ed8574ba25dfa4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cd3ea6c52ef8544c67c051a2ef489b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68f899e2c4681f4a238519bfb5b5b042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2baf849d216e689ecc40ccc931a7a7bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfa6ced76b4f3fab06a235707ee25405 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate |
2004-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d55fb834d34f6c1c677298e26dd14c3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bdf130e573a4d4f0aac5c8b6ac63dc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d1c87d2473f822f51c3e6f297a09f83 |
| publicationDate |
2005-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005063294-A1 |
| titleOfInvention |
Inhibitor for the formation of ϝ-secretase complex |
| abstract |
It is intended to provide an inhibitor for the formation of a Ϝ-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to provide a method of screening a substance having an effect of inhibiting the formation of an active complex of Ϝ-secretase which comprises assaying the activity of inhibiting cholesterol synthesis or quantifying cholesterol accumulated in lipid rafts in cells. It is also intended to provide a method of screening a cholesterol synthesis inhibitor, a protein geranylgeranylation regulator or an HMG-CoA reductase inhibitor which comprises assaying the effect of inhibiting the formation of an active complex of Ϝ-secretase. Moreover, it is intended to provide a method of screening an effect of a test substance on Ϝ-secretase which comprises measuring the distribution of constituents (niscastrin, APH-1, Pen-2 and so on) required by Ϝ-secretase for the formation of its active complex in cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007132292-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007028655-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7973053-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007028655-A2 |
| priorityDate |
2003-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |