| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2004-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e45907a91a49191b868b9985c69ac139
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5f38735fb744c3a487a174289705a85 |
| publicationDate |
2005-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005059135-A2 |
| titleOfInvention |
Treatment of mammals by sirna delivery into mammalian nerve cells |
| abstract |
The present invention relates to methods of affecting expression of a target gene, suitably brain-derived neurotrophic factor (BDNF) or related genes in a nerve cell in the central nervous system of a mammal. The method includes formulating and delivering an siRNA composition to a target site on the mammal to affect expression of the target gene in the nerve cell, wherein the target site is cerebrospinal space or muscle tissue innervated by a nerve cell, to down-regulate the target gene. Also disclosed are kits for use in practicing the novel methods of in vivo siRNA delivery into target cells and gene regulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006024880-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1800695-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9045739-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8829178-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008094866-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1802350-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010111522-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006024880-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8530436-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2287301-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8187823-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1802350-A4 |
| priorityDate |
2003-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |