abstract |
The present invention provides a method for screening for modulators of MEKK2 and MEKK3. In particular, the present invention provides methods of screening for modulators that recognize a phosphorylation site on MEKK2 at serine 519 or MEKK3 at serine 526. In other embodiments, the present invention concerns modulators for inhibiting dimerization of MEKK2, MEKK3, or both. In further embodiments the present invention provides prognostic and diagnostic methods for a disease state due to MEKK2 or MEKK3 activation. |