abstract |
The invention relates to a microorganism, obtained by treating Corynebacterium ammoniagenes KCCM 10488 producing 5’- Xanthylic acid as parent strain with UV radiation and mutation Derivatives such as N-methyl-N’nitro-N-nitrosoguanidine (NTG), Having a resistance to 5-fluorotryptophan which enhances Biosynthesis of N5-N10- tetrahydrofolate used for transferring Two formyl group during the process of puring biosysthesis, making It possible to accumulate 5’xanthylic acid in culture medium at a high Yield and high concentration rate same period of fermentation. |