| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be9096ce5ef99c482bb2214c1011a17e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae255deaf3da98719c429c1809d829eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdfcf975092110ad153f8af470345bf6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-713 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- |
| filingDate |
2004-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba1b85aae1a6ac60f2990ae465310421
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21af6a35efa1d27da7fee3c9289b0bd8 |
| publicationDate |
2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005054429-A2 |
| titleOfInvention |
Synthesis of the c1-c6 keto-acid synthon of the epothilones |
| abstract |
The present invention relates to alternative methods for producing keto-acid synthons, which are useful for the synthesis of epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing aldol condensation of a first aldehyde of a general formula: (I) with a carbonyl compound in the form of a ketone or a second aldehyde having a generalized formula: (II) thereby to form a first compound having a generalized formula : (III) and thereafter converting the first compound to a protected keto-`acid synthon of generalized formula: (IV) The present invention is also directed to chemical compounds useful in the synthesis of epothilones and analogs and derivatives thereof and to methods for forming each of these chemical compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111960935-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111960935-A |
| priorityDate |
2003-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |